13-membered azalides and their use as antibiotic agents

US6329345A · kind A · utility

Assignee

• PFIZER INC. · US

Inventors

• Robert J. Rafka · Stonington, US
• Barry J. Morton · Gales Ferry, US
• Colman B. Ragan · Mystic, US
• Peter Bertinato · Old Lyme, US
• John P. Dirlam · Gales Ferry, US
• Alan E. Blize · New London, US
• Carl Bernard Ziegler · East Lyme, US

Key dates

• Filing date: Nov 18, 1999
• Grant date: Dec 11, 2001
• Expiry date: Nov 18, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H17/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a method of preparing compounds of the formula 1 ##STR1## and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are antibacterial agents that may be used to treat various bacterial and protozoa infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial protozoa infections by administering the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1 and to intermediates useful in such preparation.