Patent · US Expired

Oligo-2'-deoxynucleotides and their use as pharmaceutical agents with antiviral activity

US6329346A · kind A · utility

16Cited by

2References

27Claims

0Family size

Assignee

Roche Diagnostics GMBH · DE

Inventors

Klasu Muhlegger · Polling, DE
Herbert von der Eltz · Spaichingen, DE
Frank Seela · Osnabrück, DE
Helmut Rosemeyer · Osnabrück, DE

Key dates

Filing date	Dec 16, 1997
Grant date	Dec 11, 2001
Priority date	—
Expiry date	Dec 16, 2017

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H21/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Oligodeoxyribonucleotides in which at least two 2'-deoxy-.beta.-D-erythro-pentofuranosyl groups are replaced by 2'-deoxy-.beta.-D-threo-pentofuranosyl groups at both the 5' end and 3' end, and oligodeoxyribonucleotides in which at least 20% of the 2'-deoxy-.beta.-D-erythro-pentofuranosyl groups in consecutive nucleotide building blocks are replaced by 2'-deoxy-.beta.-D-threo-pentofuranosyl groups and which are composed of 6 to 100 nucleotide building blocks, are suitable for the inhibition of the expression of viral genes and oncogenes by the antisense principle and can be used for the production of pharmaceutical agents with antiviral activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.