Cinnamic acid derivatives
US6329362A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 16, 1999 |
| Grant date | Dec 11, 2001 |
| Priority date | — |
| Expiry date | Mar 16, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of formula (1) are described: ##STR1## wherein PA1 L.sup.1 is a covalent bond or a linker atom or group; PA1 R is a carboxylic acid (--CO.sub.2 H) or a derivative threof; PA1 R.sup.6 and R.sup.7 which may be the same or different is each an atom or group --L.sup.2 (Alk.sup.2).sub.t L.sup.3 R.sup.12 in which L.sup.2, L.sup.3, Alk.sup.2 and t are as previously defined and R.sup.12 is a hydrogen or halogen atom or an --OR.sup.9, --NR.sup.9 R.sup.10, --NO.sub.2, --CN, --CO.sub.2 R.sup.9, --CONR.sup.9 R.sup.10, --COR.sup.9, --N(R.sup.9)COR.sup.10, --N(R.sup.9)CSR.sup.10, --SO.sub.2 N(R.sup.9)(R.sup.10), --N(R.sup.9)SO.sub.2 R.sup.9, --N(R.sup.9)CON(R.sup.10)(R.sup.11), --N(R.sup.9)CSN(R.sup.10)(R.sup.11), --N(R.sup.9)SO.sub.2 N(R.sup.10)(R.sup.11), or an optionally substituted aliphatic, heteroaliphatic, cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group provided that R.sup.6 and R.sup.7 are not both hydrogen atoms and when R.sup.7 is a hydrogen atom then R.sup.4 and R.sup.5 is each a hydrogen or halogen atom or an alkyl, alkoxy or nitro group; and the salts, solvates, hydrates and N-oxides thereof, for use in modulating cell adhesion. The compounds are abl…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.