Hydrazone, hydrazine and thiosemicarbazone derivatives as antifungal agents

US6329378A · kind A · utility

Assignee

• ANADYS PHARMACEUTICALS, INC. · US

Inventors

• Xiaodan Mei · Waltham, US
• Peng Wang · Carlsbad, US
• Andrei Caracoti · Waltham, US
• Pamela Mingo · Lake Forest, US
• Vincent A. Boyd · Tyler, US
• Robert J. Murray · Yarmouth, US
• Nicholas J. Sisti · Jeffersonville, US
• Yi Bin Xiang · Acton, US
• Shuhao Zhu · Waltham, US
• C. Richard Wobbe · Lexington, US
• Daniel J. Moore · Nashville, US

Key dates

• Filing date: Feb 10, 2000
• Grant date: Dec 11, 2001
• Expiry date: Feb 10, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are pharmaceutical compositions comprising aryl and heteroaryl hydrazone, hydrazine and thiosemicarbazone derivatives of formulae I and II, and methods for using the compositions as antifungal agents. The invention also relates to novel aryl and heteroaryl hydrazone, hydrazine and thiosemicarbazone derivatives of formulae I and II, their preparation, to pharmaceutical compositions containing them, and to methods of using them to alleviate fungal infections.