Hepatitis C inhibitor tri-pepitides
US6329417A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 1, 2000 |
| Grant date | Dec 11, 2001 |
| Priority date | — |
| Expiry date | Nov 1, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/005
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Racemates, diastereolsomers and optical isomers of a compound of formula (I): ##STR1## wherein B is H, a C.sub.6 or C.sub.10 aryl, C.sub.7-16 aralkyl; Het or (lower alkyl)-Het, all of which optionally substituted with C.sub.1-6 alkyl; C.sub.1-6 alkoxy; C.sub.1-6 alkanoyl; hydroxy; hydroxyalkyl; halo; haloalkyl; nitro; cyano; cyanoalkyl; amino optionally substituted with C.sub.1-6 alkyl; amido; or (lower alkyl)amide; or PA1 B is an acyl derivative of formula R.sub.4 --C(O)--; a carboxyl of formula R.sub.4 --O--C(O)--; an amide of formula R.sub.4 --N(R.sub.5)--C(O)--; a thioamide of formula R.sub.4 --N(R.sub.5)--C(S)--; or a sulfonyl of formula R.sub.4 --SO.sub.2 ; R.sub.5 is H or C.sub.1-6 alkyl; and PA1 Y is H or C.sub.1-6 alkyl; PA1 R.sup.3 is C.sub.1-8 alkyl, C.sub.3-7 cycloalkyl, or C.sub.4-10 alkylcycloalkyl, all optionally substituted with hydroxy, C.sub.1-6 alkoxy, C.sub.1-6 thioalkyl, amido, (lower alkyl)amido, C.sub.6 or C.sub.10 aryl, or C.sub.7-16 aralkyl; PA1 R.sub.2 is CH.sub.2 --R.sub.20, NH--R.sub.20, O--R.sub.20 or S--R.sub.20, wherein R.sub.20 is a saturated or unsaturated C.sub.3-7 cycloalkyl or C.sub.4-10 (alkylcycloalkyl), all of which being optionally mono-, di-…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.