Nonpeptide insulin receptor agonists
US6329431A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 21, 1997 |
| Grant date | Dec 11, 2001 |
| Priority date | — |
| Expiry date | Aug 21, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/9121
- WIPO fieldAudio-visual technology
- WIPO sectorElectrical engineering
Abstract
Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula ##STR1## PA1 wherein each A is independently a proton-accepting substituent; PA1 each R is independently a noninterfering substituent; PA1 m is 0 or 1; PA1 n is 0, 1, or 2; and PA1 each linker is independently --NHCNHNH--, --NHCOO--, OCOO--,--CH.dbd.CH--, --CH.dbd.N--, --CH.sub.2 CH.sub.2 --, --NHCH.sub.2 --, --OCO-- or --COO--. Compounds in the genus of Formula (1) can also be used for structure activity studies to identify features responsible for the relevant activities.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.