Transferrin receptor reactive chimeric antibodies
US6329508A · kind A · utility
65Cited by
21References
4Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jul 5, 1994 |
| Grant date | Dec 11, 2001 |
| Priority date | — |
| Expiry date | Jul 5, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/81
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention pertains to chimeric antibodies that are reactive with transferrin receptors on brain capillary endothelial cells. These antibodies are composed of a variable region, immunologically reactive with the transferrin receptors, that is obtained from one animal source, and a constant region that is derived from an animal source other than the one that provided the variable region. These chimeric antibodies can exist either as isolated entities or as conjugates with a neuropharmaceutical agent for transferal across the blood brain barrier.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.