Bio-inorganic compound capable of stable, solid-state storage of genes and preparation thereof
US6329515A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 10, 1999 |
| Grant date | Dec 11, 2001 |
| Priority date | — |
| Expiry date | Sep 10, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/1003
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed is a bio-inorganic hybrid composite for retaining and carrying bio-materials with stability and reversible dissociativity, represented by the following chemical Formula I and a method for preparing the same. The bio-inorganic hybrid composite is prepared by (a) coprecipitating with an alkaline material an aqueous solution comprising a bivalent metal (M(II)) and a trivalent metal (N(III)) at a molar ratio satisfying the condition of 1/5.ltoreq.b/(a+b).ltoreq.1/2 wherein a and b represent a mole number of M and N, respectively, to form a stable layered double hydroxide in which anions are intercalated and (b) subjecting the intercalated anions to ion exchange reaction with a bio-material to compensate for layer charges of the layered double hydroxide. This composite is harmless to the body and artificially controls the appropriate expression of the bio-material retained therein. EQU [M.sup.2+.sub.1-x N.sup.3+.sub.x (Oh).sub.2 ][A.sub.BIO.sup.n- ].sub.x/n.yH.sub.2 O [I] wherein, PA1 M is a bivalent metal cation; PA1 N is a trivalent metal cation; PA1 A.sub.BIO is an anionic bio-material with n charges; PA1 x is a rational number between 0 to 1; and PA1 y is a positive number…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.