Optical diagnostic agents for diagnosis of neurodegenerative diseases by means of near infrared radiation (NIR radiation)

US6329531A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Jonathan S. Turner · Evanston, US
• Thomas Dyrks
• Wolfhard Semmler · Glienicke, DE
• Kai Licha · Berlin, DE
• Bjorn Riefke · Berlin, DE

Key dates

• Filing date: Nov 18, 1999
• Grant date: Dec 11, 2001
• Expiry date: Nov 18, 2019

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of formula (I): F.sub.m (--A1)(--B.sub.n)(--W.sub.o) wherein F is a colorant-signal molecule with a maximum absorption value ranging from 600-1200 nm; A is a .beta.-amyloid plaque binding biomolecule; B is a .beta.-amyloid plaque binding colorant; and W is a .beta.-amyloid plaque binding hydrophilic low-molecular structural element. The invention also describes the use of these compounds in in vivo an din vitro diagnosis of neurodegenerative diseases such as Alzheimer's disease by means of near infra-red radiation (NIR radiation) as a constrasting agent in fluoresecence and transillumination diagnosis in the NIR range. Diagnostic agents containing said componenets are also disclosed.