Tissue specimen holder
US6330106A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 17, 2000 |
| Grant date | Dec 11, 2001 |
| Priority date | — |
| Expiry date | Feb 17, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/0364
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A tray or holder for tissue specimens, especially of excised tissue, such as biopsied specimens, is used with a confocal imaging system, especially a laser scanning confocal microscope system. The tray may be disposable after imaging of the specimen carried therein or may archive the specimen. A window supports the specimen. Clamps mounted inside the tray restrain the tissue. A compliant bag is mounted outside the tray on one side of a window of the tray on which the specimen is disposed. During imaging the specimen is immersed in a liquid contained in the tray having an index of refraction which closely matches the index of refraction of the tissue. The bag also contains an index matching liquid preferably having the same index as the liquid in the tray. A stabilizing plate is attached to a surface of the bag which faces the window. Selecting an immersion liquid, which equals the refractive index of the near surface tissues, minimizes wavefront distortion which may result from an effectively corrugated surface of the specimen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.