Reduction of interference of immunoassays by substances derived from the framework regions of antibodies

US6331402A · kind A · utility

Assignee

• Roche Diagnostics GMBH · DE

Inventors

• Sabine Nussbaum · Iffeldorf, DE
• Ellen Moessner · Vellberg, DE
• Helmut Lenz · Tutzing, DE
• Gerald Praast · Schlangenbad, DE

Key dates

• Filing date: Jun 25, 1999
• Grant date: Dec 18, 2001
• Expiry date: Jun 25, 2019

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/5306
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention concerns an immunological process for the detection of an analyte in a sample, in particular of tumor markers wherein for the reduction of interference substances containing a peptide sequence derived from the framework regions of the variable domain of the antibodies to be detected or the antibodies used for immune therapy or scintigraphy are added to the test preparation. Furthermore, the invention concerns the use of such substances for the reduction of interference of immunoassays, a suppressive agent and a process for the reduction of interference of immunoassays by the substances mentioned.