Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production
US6331408A · kind A · utility
21Cited by
12References
58Claims
0Family size
Inventors
Key dates
| Filing date | Nov 12, 1999 |
| Grant date | Dec 18, 2001 |
| Priority date | — |
| Expiry date | Nov 12, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/968
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifying macromolecules involved in APP processing and beta-amyloid production. Furthermore, inhibitors identified by the screening method of the present invention are useful in the treatment of neurological disorders, such as Alzheimer's disease, which involve elevated levels of A.beta. peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.