Modified forms of Hepatitis C NS3 protease for facilitating inhibitor screening and structural studies of protease: inhibitor complexes
US6333186A · kind A · utility
11Cited by
6References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 6, 2000 |
| Grant date | Dec 25, 2001 |
| Priority date | — |
| Expiry date | Jan 6, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to modified Hepatitis C NS3 proteases and modified Hepatitis C NS4a-NS3 fusion proteases. These proteins are highly soluble and are useful for NMR spectroscopy, X-ray crystallography, and inhibitor screening. DNA constructs are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.