Method based on localization of Hsp90 to the centrosome
US6335157B1 · kind B1 · utility
7Cited by
0References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 7, 1999 |
| Grant date | Jan 1, 2002 |
| Priority date | — |
| Expiry date | May 7, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6875
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention is directed to methods for screening for fragments, derivatives and analogs of Hsp90 that are altered in their subcellular localization, and thus, altered in their activity as compared to wild type Hsp90. The present invention is also directed to screening for modulators of Hsp90 activity as determined by assaying for altered subcellular localization of Hsp90. The present invention is further directed to diagnostic, prognostic and screening uses of Hsp90/centrosome co-purification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.