Resolution of chiral amines
US6335187B1 · kind B1 · utility
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Key dates
| Filing date | Jun 6, 2000 |
| Grant date | Jan 1, 2002 |
| Priority date | — |
| Expiry date | Jun 6, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P13/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Chiral amines are resolved by selectively reacting an enantiomer of the amine with an alkyl ester in the presence of an enantioselective lipase enzyme to produce an amide of that enantiomer and separating it from the unreacted enantiomer, the alkyl group of the ester being an isoalkyl group. Isobutyl and especially isopropyl groups are preferred.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.