Beta lactam compounds and their use as inhibitors of tryptase

US6335324B1 · kind B1 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Gregory S. Bisacchi · Lawrenceville, US
• William A. Slusarchyk · Montgomery, US
• Uwe D. Treuner · Etterzhausen, DE
• James Sutton · Princeton Junction, US
• Robert Zahler · Pennington, US
• Steven Seiler · Pennington, US
• David Kronenthal · Yardley, US
• Michael E. Randazzo · Tampa, US
• Mark D. Schwinden · Holland, US
• Zhongmin Xu · Princeton, US
• Zhongping Shi · Plainsboro, US

Key dates

• Filing date: Dec 13, 1999
• Grant date: Jan 1, 2002
• Expiry date: Dec 13, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D205/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.