Orally active iron (III) chelators
US6335353B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 10, 1999 |
| Grant date | Jan 1, 2002 |
| Priority date | — |
| Expiry date | Nov 10, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel 3-hydroxypyridin-4-one compound of formula I is provided whereinR is hydrogen or a group that is removed by metabolism in vivo to provide the free hydroxy compound,R1 is an aliphatic hydrocarbon group or an aliphatic hydrocarbon group substituted by a hydroxy group or a carboxylic acid ester, sulpho acid ester or a C1-6 alkoxy, C6-aryloxy or C7-10aralkoxy ether thereof,R3 is selected from hydrogen and C1-6alkyl;and R4 is selected from hydrogen, C1-6alkyl and a group as described for R2;characterised in thatR2 is selected from groups—CONH—R5  (i)—CH2NHCO—R5  (ii)—SO2NH—R5  (iii)—CH2NHSO2—R5  (iv)—CR6R6OR7  (v)—CONHCOR5  (viii) whereinR5 is selected from hydrogen and optionally hydroxy, alkoxy, or aralkoxy substituted C1-13 alkyl, aryl and C71-13 aralkyl,R6 is independently selected from hydrogen, C1-13 alkyl, aryl and C7-13 aralkyl,and R7 is selected from hydrogen, C1-13 alkyl, aryl and C7-13 aralkyl or a pharmaceutically acceptable salt of any such compoundwith the proviso that when R7 is hydrogen, R6 is not selected from aryl and with th…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.