Synthetic spiroketal pyranes as potent anti-cancer agents
US6335364B1 · kind B1 · utility
8Cited by
3References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 29, 1999 |
| Grant date | Jan 1, 2002 |
| Priority date | — |
| Expiry date | Jun 29, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/47
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel tubulin binding compounds (SPIKETS) having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The compounds are adapted to interact favorably with a novel SP binding pocket on tubulin, which pocket is useful for screening of anti-tubulin, anti-proliferation, and anti-cancer drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.