Five-membered heterocycles having biphenylsulfonyl substitution, with sulfonylcyanamide side chain, compositions containing them, and methods of using them

US6335451B1 · kind B1 · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Heinz-Werner Kleemann · Bischofsheim, DE
• Hans-Jochen Lang · Hofheim, DE
• Jan-Robert Schwark · Frankfurt am Main, DE
• Andreas Weichert · Egelsbach, DE
• Sabine Faber · Idstein, DE
• Hans-Willi Jansen · Niedernhausen, DE

Key dates

• Filing date: Jan 21, 1998
• Grant date: Jan 1, 2002
• Expiry date: Jan 21, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them. Compounds of the formula I in which the symbols have the meanings indicated in the claims, have outstanding antiarrhythmic properties and exhibit a cardioprotective component. They can preventively inhibit or greatly decrease the pathophysiological processes in the formation of ischemically induced damage, in particular in the elicitation of ischemically induced cardiac arrhythmias. Moreover, they have a potent inhibitory action on the proliferation of cells.