Substituted benzenesulfonylureas and thioureas-process for their preparation and their use as pharmaceuticals

US6335467B1 · kind B1 · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Heinrich Englert · Hofheim, DE
• Dieter Mania · Königstein, DE
• Jens Hartung · Rodgau, DE
• Heinz Gogelein · Frankfurt am Main, DE
• Joachim Kaiser · Frankfurt am Main, DE
• Wolfgang Linz · Mainz, DE
• David Wettlauper · Frankfurt am Main, DE

Key dates

• Filing date: Jan 24, 2000
• Grant date: Jan 1, 2002
• Expiry date: Jan 24, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C335/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Benzenesulfonylureas and -thioureas of the formula I where R(1) in N or (fluoro)methyl, R(2) is H, Hal or (fluoro)(mercapto)alk(oxy)yl, E is O or S, Y is —[CR(3)2]n—, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO2 or alk(yl)oxy, are described.The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.