Screen for compounds with affinity for nucleic acids
US6337183B1 · kind B1 · utility
1Cited by
36References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 6, 1996 |
| Grant date | Jan 8, 2002 |
| Priority date | — |
| Expiry date | Sep 6, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B50/06
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods for high-throughput screening for bioactive compounds, in particular those that bind to RNA sequences involved in the pathogenesis of disease or in regulation of a physiological function. The methods involve measuring the conformation of an RNA target in the presence and absence of test ligands, and identifying as a ligand any test ligand that causes a measurable change in target RNA conformation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.