Enzymatic processes for preparing (S)-cyanohydrins

US6337196B1 · kind B1 · utility

Assignee

• DSM Fine Chemicals Austria NFG GmbH & Co KG · AT

Inventors

• Gerald Kirchner · Wesel, DE
• Irma Wirth · Ansfelden, AT
• Christian Werenka · Ansfelden, AT
• Herfried Griengl · Graz, AT
• Michael Schmidt · Weiterstadt, DE

Key dates

• Filing date: Jun 25, 1999
• Grant date: Jan 8, 2002
• Expiry date: Jun 25, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/001
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

An enantioselective process for the preparation of the (S)-enantiomer of an optically active cyanohydrin by reaction of an aldehyde or of a ketone with a cyanide group donor, in which the aldehyde or the ketone is reacted with a cyanide group donor in an organic diluent in the presence of a recombinant (S)-hydroxynitrile lyase from Hevea brasiliensis and the (S)-cyanohydrin formed is isolated from the reaction mixture.