Pharmaceutical compositions and methods for use

US6337351B1 · kind B1 · utility

Assignee

• Targacept, Inc. · US

Inventors

• Gary Maurice Dull · Lewisville, US
• Jared Miller Wagner · Stillwater, US
• William Scott Caldwell · Winston-Salem, US
• Craig Harrison Miller · Winston-Salem, US
• Jeffrey Daniel Schmitt · Winston-Salem, US
• Balwinder Singh Bhatti · Winston-Salem, US
• Srishailkumar B. Hadimani · Winston-Salem, US

Key dates

• Filing date: Sep 8, 1999
• Grant date: Jan 8, 2002
• Expiry date: Sep 8, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C233/43
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pharmaceutical compositions aryl substituted amine compounds, and in particular, 3-aminophenyl amine compounds are provided. Representative compounds are (4E)-N-methyl-5-(3-acetamido-4-methylphenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3-amino-4-methylphenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3-(dimethylamino)phenyl)-4-penten-2-amine, (4E)-N-methyl-5-(4-methyl-3-nitrophenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3-fluorophenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3,4-dichlorophenyl)-4-penten-2-amine and (4E)-N-methyl-5-(3,4-methylenedioxyphenyl)-4-penten-2-amine.