Genomic nucleic acids, cDNA and mRNA which code for polypeptides with IL-16 activity, processes for the production thereof and their use

US6338844B1 · kind B1 · utility

Assignee

• Bundesrepublik Deutschland vertreten durch den Bundesminister fur Gesundheit · DE

Inventors

• Reinhard Kurth · Neu-Isenburg, DE
• Michael Baier · Frankfurt, DE
• Norbert Bannert · Frankfurt, DE
• Karin Metzner · Frankfurt, DE
• Albrecht Werner · Weinheim, DE

Key dates

• Filing date: May 11, 1999
• Grant date: Jan 15, 2002
• Expiry date: May 11, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A nucleic acid with which expression of a polypeptide having interleukin-16 activity can be achieved or regulated in a prokaryotic or eukaryotic host cell, wherein in the region coding for the polypeptide, the nucleic acid (1) corresponds to the DNA sequence SEQ ID NOS:1 and 5-7 or its complementary strand; (b) hybridizes under stringent conditions with the DNA of sequence SEQ ID NOS:1 and 5-7; (c) or is a nucleic acid sequence which, if there was no degeneracy of the genetic code, would hybridize under stringent conditions with the nucleic acid sequences defined by (a) and (b); (d) and, if it codes for a polypeptide having interleukin-16 activity, is suitable as genomic DNA for the recombinant production of IL-16 in eukaryotic host cells and processes for producing the same and pharmaceutical compositions containing the same.