Use of a non-mammalian DNA virus to express an exogenous gene in a mammalian cell
US6338962B1 · kind B1 · utility
15Cited by
16References
18Claims
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Assignee
Inventor
Key dates
| Filing date | May 26, 2000 |
| Grant date | Jan 15, 2002 |
| Priority date | — |
| Expiry date | May 26, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/85
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are methods, nucleic acids, and cells for expressing an exogenous gene in a mammalian cell, involving introducing into the cell a non-mammalian DNA virus (e.g., a baculovirus) whose genome carries an exogenous gene, and growing the cell under conditions such that the gene is expressed. Also disclosed are methods for treating gene deficiency disorders, neurological disorders, or cancers in a mammal by providing to a cell a therapeutically effective amount of a virus whose genome carries an exogenous, therapeutic gene and growing the cell under conditions such that the exogenous gene is expressed in the mammal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.