Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
US6339064B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 22, 1999 |
| Grant date | Jan 15, 2002 |
| Priority date | — |
| Expiry date | Nov 22, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H13/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure whereinY is C or N;where n is 0-3;X is R1, and R2 are independently, hydrogen, alkyl of 1 to 6 carbon atoms, or halo, acetyl, phenyl, CF3, CN, OH, NO2, NH2, alkoxy of 1 to 6 carbon atoms, or cyanoalkoxy of 2 to 7 carbon atoms;R3 is hydrogen, acylamide of 2 to 6 carbon atoms or alkoxy of 1 to 6 carbon atoms;R4, R5, R6, R7, and R8 are each, independently, acyl of 1 to 6 carbon atoms, benzyl substituted with R1, and R2; or benzoyl substituted with R1 and R2;R9 and R10 are each, independently, acyl of 1 to 6 carbon atoms, or the R9 and R10 groups on the 4′ and 6′ positions of the maltose may be taken together to form a cyclic acetal which may be substituted with alkyl of 1 to 6 carbon atoms, two alkyl groups each having 1 to 6 carbon atoms, pyridine substituted with R1, phenyl substituted with R1, benzyl substituted with R1, 2-phenylethyl substituted with R1, or 3-phenylpropyl substituted with R1;with the provisio that when R1 or R2 are cyanoalkoxy of 2-7 carbon atoms, R3 is not acylamide, and further provided that when R1, R2, or R3 are alkoxy of 1-6 carbon atoms, at least…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.