Antisense oligonucleotide modulating cyclin E gene expression and therapeutic uses thereof
US6339071B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 20, 2000 |
| Grant date | Jan 15, 2002 |
| Priority date | — |
| Expiry date | Jan 20, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/315
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to antisense oligonucleotides directed to the human cyclin E gene for inhibiting its expression, and to a method for inhibiting cellular proliferation. The antisense oligonucleotides of the present invention have been designed from the 5′ and 3′-untranslated region of the cyclin E gene for inhibiting the expression of the cyclin E gene. These antisense oligonucleotides can be used for research purposes, diagnostics and treatment of disease. Methods for specifically modulating cyclin E expression in cells and tissues using the antisense oligonucleotides are disclosed. Methods for diagnosis, detection and treatment of pathologies involving cyclin E gene are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.