Urethanes derived from azacycloalkanes, the thio and dithio analogues thereof and their use as cholesterol biosynthesis inhibitors

US6339096B1 · kind B1 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Roland Maier · Biberach an der Riß, DE
• Rudolf Hurnaus · Großenhain, DE
• Michael Mark · Biberach an der Riß, DE
• Bernhard Eisele · Biberach, DE
• Peter-Juergen Mueller · Stamford, US
• Gebhard Schilcher · Mittelbiberach, DE
• Gebhard Adelgoss · Biberach, DE

Key dates

• Filing date: Mar 24, 1999
• Grant date: Jan 15, 2002
• Expiry date: Mar 24, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/54
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to urethanes derived from azacycloalkanes and the thio and dithio analogues thereof of general formula whereinm, n, A, X, Y, E and R1 to R8 are defined as in claim 1, the enantiomers, diastereomers and the salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis, pharmaceutical compositions containing these compounds, their use and processes for preparing them.