Compounds and methods to treat cardiac failure and other disorders

US6340685B1 · kind B1 · utility

Assignee

• SCIOS INC. · US

Inventors

• Babu J. Mavunkel · Sunnyvale, US
• John A. Lewicki · Los Gatos, US
• David Liu · Palo Alto, US
• George Schreiner · Los Altos Hills, US
• John Perumattam · Los Altos, US

Key dates

• Filing date: Mar 24, 1999
• Grant date: Jan 22, 2002
• Expiry date: Mar 24, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of the formula: and the pharmaceutically acceptable salts thereof,wherein each of Z1 and Z2 is independently CR4 or N;where each R4 is independently H or is alkyl (1-6C) optionally including one or more heteroatoms selected from O, S and N and optionally substituted by one or more of halo, OR, SR, NR2, RCO, COOR, CONR2, OOCR, or NROCR where R is H or alkyl (1-6C), or by CN or ═O, or by an aliphatic or aromatic 5 or 6 membered ring optionally containing 1-2 N heteroatoms; ortwo R4 taken together form a bridge optionally containing a heteroatom;R1 is  whereinX1 is CO or an isostere thereof;m is 0 or 1;Y is optionally substituted alkyl, optionally substituted aryl, or optionally substituted arylalkyl or two 6 taken together may form an alkyene (2-3C) bridge;n is 0 or 2;Z3 is CH or N;X2 is CH, CH2 or an isostere thereof; andAr consists of one or two phenyl moieties directly coupled to X2 optionally substituted by halo, nitro, alkyl (1-6C), alkenyl (1-6C), CN or CF3, or by RCO,COOR, CONR2, NR2, OR, SR, OOCR or NROCR wherein R is H or alkyl (1-6C)or by phenyl, itself optionally substituted by the foregoing substituents;R2 is H, or alkyl (1-6C) optionally including o…