Deuterated rapamycin compounds, method and uses thereof
US6342507B1 · kind B1 · utility
63Cited by
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6Claims
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Key dates
| Filing date | Jul 6, 1999 |
| Grant date | Jan 29, 2002 |
| Priority date | — |
| Expiry date | Jul 6, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/416
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The synthesis of deuterated analogues of rapamycin is disclosed together with a method for use for inducing immunosupression and in the treatment of transplantation rejection, graft vs host disease, autoimmune diseases, diseases of inflammation leukemia/lymphoma, solid tumors, fungal infections, hyperproliferative vascular disorders. Also described is a method for the synthesis of water soluble deuteratred rapamycin compounds and their use as described above.
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