Amphipathic coating for modulating cellular adhesion composition and methods
US6342591B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 31, 2000 |
| Grant date | Jan 29, 2002 |
| Priority date | — |
| Expiry date | Jul 31, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC09D105/10
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention provides an anti-thrombogenic and cellular-adhesion coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I: wherein R1 is an C1-18 alkyl or C6-32 aryl group, each R2 is independently selected from the group consisting of C1-18 alkyl and C6-32 aryl, R3 is N or O, n is a number from 1 to 10, directly bound to a heparin molecule via covalent bonding, with an adhesive molecule directly bound to the heparin molecule. In one embodiment, the coating comprises benzyl-(1,2 dimethyl)disilyl heparin, wherein an adhesive molecule, such as fibronectin, is bound to the heparin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.