Compositions and methods for inhibiting cox-2 expression and treating cox-2 associated disorders by using cox-2 antisense oligonucleotides
US6344323B1 · kind B1 · utility
22Cited by
6References
35Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 16, 1999 |
| Grant date | Feb 5, 2002 |
| Priority date | — |
| Expiry date | Sep 16, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/804
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention features antisense oligonucleotide molecules that specifically bind polynucleotides encoding COX-2. The present invention provides antisense oligonucleotides capable of inhibiting COX-2 expression, and methods of use thereof to reduce activity of COX-2 in tissues in order to treat diseases such as, for example, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, chronic liver disease, ulcerative colitis, cell proliferative disorders, and inflammation associated with Alzheimer's Disease and stroke.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.