Agents for promoting bone formation

US6344439B1 · kind B1 · utility

Assignee

• AVENTIS PHARMA S.A. · FR

Inventors

• Kazuyuki Kitamura · Sakado, JP
• Osamu Komiyama · Chiba, JP
• Mizuho Inazu · Saitama, JP
• Roland Baron · Paris, FR
• Thomas Gadek · Oakland, US
• Jochen Knolle · Kriftel, DE
• Hans Ulrich Stilz · Frankfurt am Main, DE
• Volkmar Wehner · Bischofsheim a.d.Rhön, DE
• Robert McDowell · San Francisco, US

Key dates

• Filing date: Jul 26, 2000
• Grant date: Feb 5, 2002
• Expiry date: Aug 5, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/78
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The object is to provide a promoting agent for bone formation, a therapeutic method for bone formation and a process for preparing a promoting agent for bone formation.A promoting agent for bone formation which comprises at least one of kistrin, echstatin, a peptide or polypeptide containing the amino acid sequence ArgGlyAsp in the molecule such as a peptide represented by Gly-Arg-Gly-Asp-Ser or a compound represented by the following general formula (IX) and so on, as well as a biologically acceptable salt thereof wherein R16 represents —N(R20)2 (R20 represents a hydrogen atom or a C1-C4 alkyl group), R17 represents a hydrogen atom or a C1-C4 alkyl group, R18 represents a hydrogen atom, a C1-C4 alkyl group and so on, R19 represents OH, NH2 and so on, Y represents —NH—, —O— or a direct bond, a represents 1-3, b represents 1 or 2, c represents 0 or 1 and d represents 0 or 1.