Antisecretory factor peptides regulating pathological permeability changes

US6344440B1 · kind B1 · utility

Assignee

• Rural Patent Svenska AB · SE

Inventors

• Ivar Lönnroth · Mölndal, SE
• Stefan Lange · Stuttgart, DE
• Eva Johansson · Mölndal, SE
• Eva Jennische · Handen, SE
• Christina Lönnroth · Mölndal, SE

Key dates

• Filing date: Mar 13, 1998
• Grant date: Feb 5, 2002
• Expiry date: Mar 13, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A new recombinant protein called Antisecretory Factor (rAF) and homologues and peptide fragments thereof are described. The protein and the homologues and fragments thereof are useful for normalizing pathological fluid transport and/or inflammatory reactions in animals including humans. Antibodics against AF or homologues or fragments thereof are described. Nucleic acids coding for the protein or for homologues or fragments thereof are also described as well as vectors and hosts comprising the nucleic acids. The rAF and homologues and fragments thereof could be used for immunodetection, as feed additive for growing animals and as antidiarrheal and drugs against diseases involving edema, dehydration and/or inflammation.