Peptide antagonists of tumor necrosis factor alpha
US6344443B1 · kind B1 · utility
29Cited by
66References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 8, 1999 |
| Grant date | Feb 5, 2002 |
| Priority date | — |
| Expiry date | Jul 8, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is provided a method of inhibiting TNF-&agr; from binding to TNF receptors by administering an effective amount of an inhibitory peptide. Also provided is a method of inhibiting TNF-&agr; functions by administering an effective amount of an inhibitory peptide. There also are provided peptides which have TNF-&agr; inhibitory properties. Also provided is a method of inhibiting TNF-&agr; binding to TNF receptors by administering an effective amount of peptides having the amino acid sequences shown in SEQ ID No. 1,2,3,4, wherein the peptides can be administered either singly or in combination.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.