Lactam compounds and their use as inhibitors of serine proteases and method
US6344450B1 · kind B1 · utility
12Cited by
12References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 7, 2000 |
| Grant date | Feb 5, 2002 |
| Priority date | — |
| Expiry date | Aug 7, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Lactam inhibitors are provided which have the structure X is whereinY is O or S and R4 is  R7O— or R8 and R1, R2, R3, R5, R6, R7, and R8, are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants, and are inhibitors of tryptase and thus are useful in treating asthma. Methods for treating cardiovascular diseases associated with thromboses and for treating asthma and related diseases are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.