Thyromimetic antiobesity agents

US6344481B1 · kind B1 · utility

Assignee

• PFIZER INC. · US

Inventors

• Peter Cornelius · Framingham, US
• Diane Hargrove · Ledyard, US
• Bradley P. Morgan · Moraga, US
• Andrew G. Swick · East Lyme, US

Key dates

• Filing date: Jan 20, 2000
• Grant date: Feb 5, 2002
• Expiry date: Jan 20, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to pharmaceutical compositions and methods useful in the treatment of obesity which methods comprise administering to animal, including a human or companion animal, in need of such treatment an effective amount of a compound of the structural formula or a pharmaceutically acceptable salt, racemate or enantiomer thereof, whereinR is hydroxy, esterified hydroxy or etherified hydroxy;R1 and R2 are, independently, halogen, trifluoromethyl or lower alkyl;R3 is halogen, trifluoromethyl, lower alkyl, aryl, aryl-lower alkyl, cycloalkyl or cycloalkyl-lower alkyl, carbocyclic arylmethyl, carbocyclic aroyl, carbocyclic arylhydroxymethyl; orR3 is the radical whereinR8 is hydrogen, lower alkyl, aryl, cycloalkyl, aryl-lower alkyl or cycloalkyl-lower alkyl;R6 is hydroxy or acyloxy; R10 is hydrogen or lower alkyl; or R9 and R10, taken together with the carbon atom to which they are attached, form a carbonyl group;R4 is hydrogen, halogen, trifluoromethyl or lower alkyl;R5 and R6 are, independently, hydrogen or lower alkyl or R5 and R6, taken together with the carbon atom to which they are attached, form a carbonyl group;X is O, S or —NR7;R7 is hydrogen or lower alkyl;W i…