Process for producing quinazoline derivatives
US6344559B1 · kind B1 · utility
6Cited by
4References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 13, 1999 |
| Grant date | Feb 5, 2002 |
| Priority date | — |
| Expiry date | Oct 13, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/96
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides an industrially useful process for producing a quinazoline derivative (I) of the general formula: [wherein R1 is hydrogen or halogen; R2 is carboxy or protected carboxy; A is lower alkylene] or its salt on a commercial scale which comprises reacting a compound of the general formula: [wherein R1 is hydrogen or halogen] or its salt with a silylating agent and then with a compound of the general formula:Cl—A—R2  (III)[wherein R2 is carboxy or protected carboxy; A is lower alkylene] or its salt, optionally followed by desilylation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.