Preparation of cycloacid
US6344565B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 22, 2000 |
| Grant date | Feb 5, 2002 |
| Priority date | — |
| Expiry date | Aug 22, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the production of 2-oxo-1,3-dibenzyl-cis-4,5-imidazolidinedicarboxylic acid starting from meso-2,3-bis(benzylamino)-succinic acid dialkali metal salt is described. This process includes reacting meso-2,3-bis(benzylamino)-succinic acid dialkali metal salt with triphosgene in a two-phase solvent system consisting of an aqueous alkali hydroxide solution and an organic solvent at a temperature not exceeding about 50° C. and converting the 2-oxo-1,3-dibenzyl-cis-4,5-imidazolidinedicarboxylic acid dialkali metal salt, which results therefrom and which is present in the aqueous phase, into the desired 2-oxo-1,3-dibenzyl-cis-4,5-imidazolidinedicarboxylic acid by acidification. The product is an important intermediate in the multi-stage process for the manufacture of biotin (vitamin H).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.