Patent · US Expired

Method for producing enantiomer-free N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrolidine-1-yl)ethyl]-2,2-diphenylacetamide

US6344566B1 · kind B1 · utility

4Cited by

4References

16Claims

0Family size

Assignee

Merck Patent GmbH · DE

Inventors

Andreas Bathe · Darmstadt, DE
Bernd Helfert · Ober-Ramstadt, DE
Karl-August Ackermann · Ober-Ramstadt, DE
Rudolf Gottschlich · Reinheim, DE
Ingeborg Stein · Langen (Hessen), DE
Jens Budak · Darmstadt, DE

Key dates

Filing date	Jan 26, 2001
Grant date	Feb 5, 2002
Priority date	—
Expiry date	Jan 26, 2021

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to a novel process for the alternative preparation of N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamide or N-methyl-N-[(1R)-1-phenyl-2-((3R)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamide, and the novel compounds N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethane] and N-methyl-N[(1R)-1-phenyl-2-((3R)-3-hydroxypyrrolidin-1-yl) ethane], which are prepared as intermediates.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.