Polypeptide-containing pharmaceutical forms of administration in the form of microparticles and method for the preparation thereof
US6346274B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 5, 1998 |
| Grant date | Feb 12, 2002 |
| Priority date | — |
| Expiry date | Jan 5, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/1816
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns parenteral pharmaceutical forms of administration containing polypeptide in the form of microparticles and a process for the production thereof. The microparticles according to the invention contain as a biodegradable polymer an ABA triblock copolymer the A block of which is a copolymer of lactic and glycolic acid and the B block of which represents a polyethylene glycol chain, together with additives that are selected from the group comprising serum proteins, polyamino acids, cyclodextrins, cyclodextrin derivatives, saccharides, amino sugars, amino acids, detergents or carboxylic acids as well as mixtures of these additives. The microparticles according to the invention continuously release the polypeptide over a relatively long time period even when the amounts of polypeptide they include are small or susceptible to aggregation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.