Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes
US6346376B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 11, 1999 |
| Grant date | Feb 12, 2002 |
| Priority date | — |
| Expiry date | May 11, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/805
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This document describes an optical sensor unit and a procedure for the specific detection and identification of biomolecules at high sensitivity in real fluids and tissue homogenates. High detection limits are reached by the combination of i) label-free integrated optical detection of molecular interactions, ii) the use of specific bioconstituents for sensitive detection and iii) planar optical transducer surfaces appropriately engineered for suppression of non-specific binding, internal referencing and calibration. Applications include the detection of prion proteins and identification of those biomolecules which non-covalently interact with surface immobilized prion proteins and are intrinsically involved in the cause of prion related disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.