Desmethyl tocopherols for protecting cardiovascular tissue
US6346544B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 27, 2001 |
| Grant date | Feb 12, 2002 |
| Priority date | — |
| Expiry date | Feb 27, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/355
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention involves the use of desmethyl tocopherols such as gamma tocopherol for the protection of cardiovascular tissue from nitrative stress. While mechanisms other than scavenging of reactive nitrogen species may be involved, desmethyl tocopherols exhibit significant protection and may be utilized to treat or help prevent cardiovascular particularly arterial vascular disease. The desmethyl tocopherols may be administered dietarily or parenterally when a more direct dosage is desired. Both routes may be utilized together or separately to optimize therapeutic and prophylactic benefits. The lessening of damage induced by reactive nitrogen species leads to the lessening of arterial blockage in thrombosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.