Crystalline 2-hydroxymethyl carbapenem intermediate compounds and process for synthesis thereof
US6346617B1 · kind B1 · utility
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22Claims
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Key dates
| Filing date | Jun 16, 1999 |
| Grant date | Feb 12, 2002 |
| Priority date | — |
| Expiry date | Jun 16, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparation of a compound of formula I: wherein:R1 represents CH3 or H; and P represents a protecting group;comprising reacting a compound of formula IV:  wherein R1 and P and are defined above and R4 represents triflate or SO2F;in the presence of a catalyst and (R3)3SnCH2OP″, wherein each R3 represents C1-4 lower alkyl, and P″ represents H or a protecting group, to yield the compound of formula I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.