Chromanone and thiochromanone compounds
US6346626B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 2000 |
| Grant date | Feb 12, 2002 |
| Priority date | — |
| Expiry date | Oct 6, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns the compounds of formula I whereinR1 and R2 independently are hydrogen, acyl, alkoxycarbonyl or alkyl; either the sulfamoyloxy side chain is bound to the 6 position;R3 is alkyl; alkenyl; alkinyl; a cycloalkyl moiety optionally substituted by alkyl, alkoxy or halogen; arylalkenyl; arylalkinyl; acyl; cycloalkylalkyl; 3-oxo-2-oxacamphanyl; or is 6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl; andR4 is hydrogen; alkyl; hydroxy; or alkoxy;or the sulfamoyloxy side chain is bound to the 7 position;R3 has the significance indicated above for R4; andR4 has the significance indicated above for R3;X is O or S; and the symbol - - - is a single or a double bond;in free form or salt form.They can be prepared by sulfamoylation of corresponding hydroxylated compounds, by reduction and/or by N-substitution.They are indicated for use as pharmaceuticals, particularly in the prophylactic or curative treatment of illnesses responsive to steroid sulfatase inhibition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.