Stabilization of taxane-containing dispersed systems
US6348215B1 · kind B1 · utility
13Cited by
4References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 6, 2000 |
| Grant date | Feb 19, 2002 |
| Priority date | — |
| Expiry date | Oct 6, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/127
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a method of stabilizing a taxane in a dispersed system, which method comprises exposing the taxane to a molecule which improves physical stability of the taxane in the dispersed system. By improving physical stability of the taxane in the dispersed system, higher taxane content can be achieved. The invention thus further provides a stable taxane-containing liposome preparation comprising a liposome containing one or more taxanes present in the liposome in an amount of less than 20 mol % total taxane to liposome, wherein the liposome is suspended in a glycerol:water composition having at least 30% glycerol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.