Stabilized oligonucleotides and their use

US6348312B1 · kind B1 · utility

Assignee

• Hoescht Aktiengesellschaft · DE

Inventors

• Anuschirwan Peyman · Kelkheim, DE
• Eugen Uhlmann · Königstein, DE
• Matthias Mag · Oberursel, DE
• Gerhard Kretzschmar · Eschborn, DE
• Matthias Helsberg · Kelkheim, DE
• Irvin Winkler · Liederbach, DE

Key dates

• Filing date: Nov 10, 1994
• Grant date: Feb 19, 2002
• Expiry date: Nov 10, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel stabilized oligonucleotides in which at least one non-terminal pyrimidine nucleoside is modified, and to their use as a diagnostic or pharamaceutical for the treatment of viral infections, cancer or diseases in which integrins or cell-cell adhesion receptors are active.