Catechols as antimicrobial agents

US6348482B1 · kind B1 · utility

Assignees

• MERCK & CO., INC. · US
• Cubist Pharmaceuticals LLC · US

Inventors

• Milton L. Hammond · Somerville, US
• Aaron H. Leeman · Cranford, US
• Milana Maletic · Summit, US
• Gina M. Santorelli · Long Branch, US
• Sherman T. Waddell · Westfield, US
• John Finn · Mercerville, US
• Michael Morytko · Framingham, US
• Jason Hill · Riverview, US
• Dennis Keith · Montclair, US

Key dates

• Filing date: May 5, 2000
• Grant date: Feb 19, 2002
• Expiry date: May 5, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino, acylamino, halo, alkoxy, aryloxy, carboxyamido, alkenyl, cycloalkyl, heterocyclyl, acyl, acyloxy, carboalkoxy, carboxy, thio, sulfinyl, sulfonyl and sulfoxy, R5, R6, R7, and R8 are hydrido and lower alkyl; and Het is a nitrogen-containing heterocyclic ring.