Methods for modulating bladder function
US6348486B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 15, 2001 |
| Grant date | Feb 19, 2002 |
| Priority date | — |
| Expiry date | Oct 15, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/341
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides methods and pharmaceutical compositions for maintaining bladder control or treating urinary incontinence in a mammal utilizing agonists of KCNQ potassium channels, including KCNQ2, KCNQ3, KCNQ4 and KCNQ5 potassium channels, alone or in combination. Compounds useful in these methods include the 1,2,4-triamino-benzene derivatives described in U.S. Pat. No. 5,384,330 (Dieter et al.) and the substituted 3-phenyl oxindole compounds described in U.S. Pat. No. 5,565,483 (Hewawasam et al.). Among the preferred compounds of this invention is N-[2-amino-4-(4-fluorobenzylamino)-phenyl]carbamic acid ethyl ester, also referred to as retigabine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.