Unique associated Kaposi's sarcoma virus sequences and uses thereof

US6348586B1 · kind B1 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Yuan Chang · New York, US
• Roy A. Bohenzky · Mountain View, US
• James J. Russo · New York, US
• Isidore S. Edelman · New York, US
• Patrick S. Moore · New York, US

Key dates

• Filing date: Nov 17, 1999
• Grant date: Feb 19, 2002
• Expiry date: Nov 17, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/16422
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides an isolated nucleic acid molecule which encodes Kaposi's Sarcoma-Associated Herpesvirus (KSHV) polypeptides. This invention provides an isolated polypeptide molecule of KSHV. This invention provides an antibody specific to the polypeptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine for Kaposi's Sarcoma (KS). This invention provides methods of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and of detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.